Actinomyces meyeri Causing Cerebral Abscess in a Patient on Methotrexate: A Rare Case Report and Systematic Review of the Literature

Central nervous system (CNS) actinomycosis is a rare, serious, life-threatening, suppurative infection caused by Actinomyces species. are anaerobic Gram-positive bacteria, which can be normally isolated from the polymicrobial flora of gastrointestinal- and genital tracts. They considered very low virulent bacteria to humans. However, they lead several types local or disseminated infections, if certain pathologic states immunodeficiency occur. Intracranial abscesses meyeri rarely reported in adults. In this case report, we describe 66-year-old woman who presented emergency department due progressive complaints altered sensorium low-grade fever, an A. meyeri-related brain abscess. The only risk factor was represented therapy with Methotrexate steroids.